爱华网引自：http://baike.baidu.com/view/1989417.htm#1
施一公
1、简历
1990-1995美国约翰霍普金斯大学医学院，分子生物物理学博士
1995 美国约翰霍普金斯大学医学院，博士后
1996-1997 美国史隆凯特林癌症研究中心结构生物学实验室，博士后
1998-2001 美国普林斯顿大学分子生物学系，助理教授
2001-2003 美国普林斯顿大学分子生物学系，（终身）副教授
2003-2008 美国普林斯顿大学分子生物学系，（终身）教授
2007-2008 美国普林斯顿大学分子生物学系，Warner-Lambert/Parke-Davis教授
2008-至今 清华大学生命科学学院院长，教授、博导。
2、成就
在普林斯顿大学，他运用结构生物学、生物物理和生物化学手段，研究癌症发生和细胞凋亡的分子机制。迄今为止，他在国际权威学术杂志发表学术论文百余篇，其中作为通讯作者在《细胞》发表11篇、《自然》发表7篇、《科学》发表3篇。这些工作系统地揭示了哺乳动物、果蝇和线虫中细胞凋亡通路的分子机理，已有若干研究成果申请专利，用于治疗癌症的药物研发。
因在细胞凋亡和TGF-信号传导等领域的杰出工作，2003年他被国际蛋白质学会授予鄂文西格青年科学家奖，是该奖项设立以来第一位获此殊荣的华裔学者。2005年，当选华人生物学家协会会长。
3、代表论文
(RepresentativePublications)
细胞凋亡领域
Programmed cell death (apoptosis):
1.Shiqian Qi, Yuxun Pang, Qi Hu, Qun Liu, Hua Li, Yulian Zhou,Tianxi He, Qionglin Liang, Yexing Liu, Xiaoqiu Yuan, Guoan Luo,Huilin Li, Jiawei Wang, Nieng Yan, and Yigong Shi (2010). Crystalstructure of the Caenorhabditis elegans apoptosome reveals anoctameric assembly of CED-4. Cell 141, 446-457.
2.Jong W. Yu, Philip D. Jeffrey, and Yigong Shi (2009).Mechanism of procaspase-8 activation by c-FLIPL. Proc Natl Acad SciUSA 106, 8169-8174. Epub 2009 May 4.
3.Nieng Yan, Jijie Chai, Eui Seung Lee, Lichuan Gu, Qun Liu,Jiaqing He, Jia-Wei Wu, David Kokel, Huilin Li, Quan Hao, Ding Xue,and Yigong Shi (2005). Structure of the CED-4/CED-9 complexprovides insights into programmed cell death in Caenorhabditiselegans. Nature 437, 831–837.
4.Stefan J. Riedl, Wenyu Li, Yang Chao, RobertSchwarzenbacher, and Yigong Shi (2005). Structure of the apoptoticprotease activating factor 1 (Apaf-1) bound to ADP. Nature 434,926–933.
5.Nieng Yan, Lichuan Gu, David Kokel, Jijie Chai, Wenyu Li,Aidong Han, Lin Chen, Ding Xue, and Yigong Shi (2004). Structural,Biochemical and Functional Analyses of CED-9 Recognition by thePro-apoptotic Proteins EGL-1 and CED-4. Mol. Cell 15, 999–1006.
6.Stefan J. Riedl and Yigong Shi (2004). Molecular mechanismsof caspase regulation during apoptosis. Nature Review – Mol. Cell.Biol. 5, 897–907.
7.Nieng Yan, Jia-Wei Wu, Jun R. Huh, Jijie Chai, Wenyu Li,Bruce A. Hay, and Yigong Shi (2004). Molecular mechanisms of DrICEinhibition by DIAP1 and removal of inhibition by Reaper, Hid, andGrim. Nature-Structural & Molecular Biology 11 (5),420–428.
8.Yigong Shi (2004). Caspase Activation: Revisiting theInduced Proximity model. Cell 117, 855–858.
9.Jijie Chai, Nieng Yan, Jun R. Huh, Jia-Wei Wu, Wenyu Li,Bruce A. Hay, and Yigong Shi (2003). Molecular mechanism ofReaper/Grim/Hid-mediated suppression of DIAP1-dependent Droncubiquitination. Nature-Structural Biology 10, 892-898.
10.Eric N. Shiozaki, Jijie Chai, Daniel J. Rigotti, Stefan J.Riedl, Pingwei Li, Srinivasa M. Srinivasula, Emad S. Alnemri,Robert Fairman, and Yigong Shi (2003). Mechanism of XIAP-mediatedInhibition of Caspase-9. Mol. Cell 11, 519-527.
11.Yigong Shi (2002). Mechanisms of Caspase Activation andInhibition During Apoptosis (commissioned review article). Mol Cell9, 459-470.
12.Jijie Chai Qi Wu, Eric Shiozaki, Srinivasa M. Srinivasula,Emad S. Alnemri, and Yigong Shi (2001). Crystal Structure of aCaspase Zymogen: Mechanisms of Activation and Substrate Binding.Cell107, 399-407.
13.Jia-Wei Wu, Amy Cocina, Jijie Chai, Bruce Hay, and YigongShi (2001). Structural Analysis of a Functional DIAP1 FragmentBound to Grim and Hid Peptides. Mol. Cell 8, 95-104.
14.Jijie Chai, Eric Shiozaki, Srinivasa M. Srinivasula, Qi Wu,Pinaki Datta, Emad S. Alnemri, and Yigong Shi (2001). StructuralBasis of Caspase-7 Inhibition by XIAP. Cell 104, 769-780.
15.Stephen W. Fesik and Yigong Shi (2001). Controlling theCaspases. Science 294, 1477-1478.
16.Geng Wu, Jijie Chai, Tomeka Suber, Jia-Wei Wu, Chunying Du,Xiaodong Wang, and Yigong Shi (2000). Structural Basis of IAPRecognition by Smac/DIABLO. Nature408, 1008-1012.
17.Jijie Chai, Chunying Du, Jia-Wei Wu, Saw Kyin, XiaodongWang, and Yigong Shi (2000). Structural and Biochemical Basis ofApoptotic Activation by Smac/DIABLO. Nature 406, 855-862.
18.Hongxu Qin, Srinivasa M. Srinivasula, Geng Wu, Emad S.Alnemri, Yigong Shi (1999). Structural Basis of Procaspase-9Recruitment by the Apoptotic Protease Activating Factor 1. Nature399, 549-557.
膜蛋白结构与功能领域 Membrane protein structure and function:
1.Peng Zhang, Jiawei Wang, and Yigong Shi (2010). Structureand mechanism of the S component of a bacterial ECF transporter.Nature 468, 717-720. Epub 2010 Oct 24.
2.Xiang Gao, Lijun Zhou, Xuyao Jiao, Feiran Lu, Chuangye Yan,Xin Zeng, Jiawei Wang, and Yigong Shi (2010). Mechanism ofsubstrate recognition and transport by an amino acid antiporter.Nature 463, 828-832. Epub 2010 Jan 20.
3.Yi Wang, Yongjian Huang, Jiawei Wang, Chao Cheng, WeijiaoHuang, Peilong Lu, Ya-Nan Xu, Pengye Wang, Nieng Yan, and YigongShi (2009). Structure of the formate transporter FocA reveals apentameric aquaporin-like channel. Nature 462, 467-472.
4.Xiang Gao, Feiran Lu, Lijun Zhou, Shangyu Dang, Linfeng Sun,Xiaochun Li, Jiawei Wang, and Yigong Shi (2009). Structure andMechanism of an Amino Acid Antiporter. Science 324, 1565-1568. Epub2009 May 28.
5.Xiaochun Li, Boyuan Wang, Lihui Feng, Hui Kang, Yang Qi,Jiawei Wang, and Yigong Shi (2009). Cleavage of RseA by RsePrequires a carboxyl-terminal hydrophobic amino acid following DegScleavage. Proc. Natl. Acad. Sci. USA 106, 14837-42 [Epub 2009August 18].
6.Liang Feng, Hanchi Yan, Zhuoru Wu, Nieng Yan, Zhe Wang,Philip D. Jeffrey, and Yigong Shi (2007). Structure of a Site-2Protease Family Intramembrane Metalloprotease. Science 318,1608-1612.
7.Zhuoru Wu, Nieng Yan, Liang Feng, Adam Oberstein, HanchiYan, Rosanna P. Baker, Lichuan Gu, Philip D. Jeffrey, Sinisa Urban,and Yigong Shi (2006). Structural analysis of a rhomboid familyintramembrane protease reveals a gating mechanism for substrateentry. Nature Structural & Molecular Biology 13,1084-1091. 2006 Nov 10; [Epub ahead of print].
蛋白去磷酸化酶领域
Protein phosphatase 2A (PP2A):
1.Yigong Shi (2009). Structure and Mechanism of ProteinSerine/Threonine Phosphatases. Cell 139, 468-484.
2.Yongna Xing, Zhu Li, Yu Chen, Philip D. Jeffery, and YigongShi (2008). Structural Mechanism of Demethylation and Inaction ofProtein Phosphatase 2A. Cell 133, 154-163.
3. Yu Chen, Yanhui Xu, Qing Bao, Yongna Xing, Zhu Li, ZhengLin, Jeffry Stock, Philip P. Jeffrey, Yigong Shi (2007) Structuraland biochemical insights into the regulation of protein phosphatase2A by small t antigen of SV40. Nature Struct Mol Biol. 14(6),527-34. Epub 2007 May 27.
4.Yanhui Xu, Xing Yongna, Yu Chen, Yang Chao, Zheng Lin,Eugene Fan, Jong W. Yu, Stefan Strack, Philip D. Jeffrey, andYigong Shi (2006). Structure of the Protein Phosphatase 2AHoloenzyme. Cell 127, 1239–1251.
5.Xing Yongna, Yanhui Xu, Yu Chen, Philip D. Jeffrey, YangChao, Zheng Lin, Zhu Li, Stefan Strack, Jeffry B Stock, and YigongShi (2006). Structure of Protein Phosphatase 2A Bound toTumor-inducing Toxins. Cell 127, 341-352.
6.Yang Chao, Yongna Xing, Yu Chen, Yanhui Xu, Zheng Lin, ZhuLi, Philip D. Jeffrey, Jeffry B. Stock and Yigong Shi (2006).Structure and Mechanism of the Phosphotyrosyl PhosphataseActivator. Mol. Cell 23, 535-546.
蛋白降解与质量控制领域 Protein degradation and quality control:
1.Feng Wang, Ziqing Mei, Yutao Qi, Chuangye Yan, Siheng Xiang,Qi Hu, Jiawei Wang, and Yigong Shi. (2010) Structure and mechanismof the hexameric MecA-ClpC molecular machine. Nature,2011 Mar 2.[Epub ahead of print].
2.Fan Zhang , Zhuoru Wu, Ping Zhang, Geng Tian, Daniel Finley,and Yigong Shi (2009). Mechanism of substrate unfolding andtranslocation by the regulatory particle of the proteasome fromMethanocaldococcus jannaschii. Mol Cell 34, 485-496.
3.Fan Zhang , Min Hu, Geng Tian, Ping Zhang, Daniel Finley,Philip D. Jeffrey, and Yigong Shi (2009). Structural insights intothe regulatory particle of the proteasome from Methanocaldococcusjannaschii. Mol Cell 34, 473-484.
4.Nieng Yan and Yigong Shi (2007). Allosteric Activation of aBacterial Stress Sensor. Cell 131, 441-443.
5.Min Hu, Lichuan Gu, Muyang Li, Philip D. Jeffrey, Wei Gu,and Yigong Shi (2006). Structural Basis of Competitive Recognitionof p53 and MDM2 by HAUSP/USP7: Implications for the Regulation ofthe p53/MDM2 Pathway. PloS Biology 4, e27.
6.Min Hu, Pingwei Li, Ling Song, Philip D. Jeffrey, Tatiana A.Chenova, Keith D. Wilkinson, Robert E. Cohen, and Yigong Shi(2005). Structure and mechanisms of the proteasome-associateddeubiquitinating enzyme USP14. EMBO J. 24, 3747-3756. Epub 2005Oct. 6.
7.Min Hu, Pingwei Li, Muyang Li, Wenyu Li, Tingting Yao,Jia-Wei Wu, Wei Gu, Robert E. Cohen, and Yigong Shi (2002). CrystalStructure of a UBP-family Deubiquitinating Enzyme in Isolation andin Complex with Ubiquitin Aldehyde. Cell 111, 1041-1054.
SMAD蛋白信号转导领域
SMAD proteins in TGF-b signaling:
1.Yigong Shi and Joan Massagué (2003). Mechanisms of TGF-bsignaling from Cell Membrane to the Nucleus. (commissioned reviewarticle) Cell 113, 685-700.
2.Jia-Wei Wu, Ariel R. Krawitz, Jijie Chai, Wenyu Li, FangjiuZhang, Kunxin Luo, and Yigong Shi (2002). Structural Mechanism ofSmad4 Recognition by the Nuclear Oncoprotein Ski: Insight onSki-Mediated Repression of TGF-b Signaling. Cell 111, 357-367.
3.Jia-Wei Wu, Min Hu, Jijie Chai, Morgan Huse, Carey Li, SawKyin, Robert Fairman, Tom Muir, Joan Massagué, and Yigong Shi(2001). Crystal Structure of a Phosphorylated Smad2: Recognition ofPhosphoserine Motif and Insights on Smad Function in TGF-bSignaling. Mol. Cell 8, 1277-1289.
4.Geng Wu, Ye-Guang Chen, Barish Ozdamar, Cassie Gyuricza, P.Andrew Chong, Jeffrey L. Wrana, Joan Massagué, and Yigong Shi(2000). Structural Basis of Smad2 Recruitment by the Smad Anchorfor Receptor Activation (SARA). Science 287, 92-97.
5.Yigong Shi, Yan-Fei Wang, Lata Jayaraman, Haijuan Yang, JoanMassagué, and Nikola Pavletich (1998). Crystal Structure of A SmadMH1 Domain Bound to DNA: Insights on DNA-binding in TGF-bSignaling. Cell, 94, 585-594.
6.Yigong Shi, Akiko Hata, Joan Massagué and Nikola P.Pavletich (1997) A structural basis for mutational inactivation ofthe tumour suppressor Smad4. Nature 388, 87-93.
