爱华网《美国癌症研究协会》2015年会期间介绍了华人学者郭方建等人最新研究发现：接种了4价HPV疫苗女性受其他高危HPV毒株感染率大约为61%，而未接种这种HPV疫苗女性受其他高危HPV毒株感染率大约为40%。还发现接种4价HPV疫苗Gardasil的女性感染HPV6、11、16或18毒株感染率大约11%，未接种女性感染率近20%。也就是说：接种4价HPV疫苗以后，不是不再受到疫苗所含4种毒株感染，而是受感染率减少大约9%！研究者们推荐：接受4价HPV疫苗者应当再接种预防9种毒株的9价HPV疫苗，尽管该项研究发现：尚未受到HPV病毒感染年轻女性、少女与女童从这种最新的9价疫苗获得的理论上最大限度益处仅仅是预防宫颈癌的20%！【评论：HPV疫苗接种显然不仅“得不偿失”，而且竭力挺“宫颈癌疫苗”专家已思维定式，根本想象不到“HPV疫苗接种女性更容易受疫苗中未含HPV毒株以外其它高危HPV毒株感染”最有可能的原因是“宫颈癌疫苗”接种本身削弱了而不是增强了女性抵抗其他HPV病毒感染的免疫能力！】
Women Who Received HPV Vaccine May Need Another Shot
生命科学：接种了HPV疫苗女性可能需要再接种一剂
http://www.livescience.com/50563-hpv-vaccine-infections-prence.html
By Rachael Rettner, Senior Writer | April 22, 2015 07:09am ET
作者：蕾切尔×高级记者，2015年4月22日
University of Miami pediatrician Judith L. Schaechter, M.D. gives an HPV vaccination to a 13-year-old girl in her office at the Miller School of Medicine on September 21, 2011 in Miami, Florida.
迈阿密大学儿科医生朱迪斯×L·遂科特，医学博士，2011年9月21日在迈阿密米勒医学院办公室为一位13岁少女接种HPV疫苗。
PHILADELPHIA — Women who receive the human papillomavirus (HPV) vaccine may be more likely to be infected with certain high-risk strains of the virus than women who do not get the vaccine, according to a new study.
费城 -- 接种人乳头状瘤病毒（HPV）疫苗的女性可能比没有接种这种疫苗更为容易受到某些高危病毒株感染，依据一项新的研究。
The findings suggest that, although the vaccine is effective in protecting against four strains of HPV, women who received it may still benefit from getting another, recently approved HPV vaccine that protects against nine strains of the virus, the researchers said.
该项研究发现，尽管4价HPV疫苗对预防4种人乳头状瘤病毒（HPV）株有效，接种了HPV疫苗的女性可能从再接种最近刚刚批准的对付9种HPV病毒的9价HPV疫苗受益，研究者们说。
"Vaccinated women who got the quadrivalent [four-strain] vaccine may get the nine-valent [strain] vaccine as further protection for them," said Fangjian Guo, a postdoctoral fellow at the University of Texas Medical Branch and one of the researchers on the new study. Guo noted that this is not an official recommendation, and that more research is needed to confirm the findings.
“接受了4价（4种病毒株）HPV疫苗的女性可能应当再接种9价（9种病毒株）疫苗来进一步保护她们”，郭方建说，他是特克萨斯大学医学院做博士后研究生，该项研究研究者之一。郭方建指出，这不是一项官方推荐，因为需要更多研究来确认该项发现。
Currently, the Centers for Disease Control and Prevention recommends that girls and young women ages 9 to 26 get any HPV vaccine to protect against cervical cancer, as some strains of HPV have been linked to cervical cancer.
目前，美国疾控中心推荐9-26岁的女童、少女与女性接种任何HPV疫苗保护她们预防宫颈癌，因为某些HPV病毒株与宫颈癌关联。
The new study was presented this week here at the meeting of the American Association for Cancer Research. It has not yet been published in a peer-reviewed journal.
美国癌症研究协会2015年年会期间介绍了该项新的研究。他还没有在经同行审查的杂志上发表。
Title: Comparison of HPV prevalence between HPV-vaccinated and non-vaccinated young adult women (20-26 years),
标题：接种过HPV疫苗与未接种过这种疫苗年轻成年女性（20-26岁）之间HPV病毒感染发病率比较，
Authors: Fangjian Guo, Jacqueline M. Hirth, Abbey B. Berenson.
作者：Fangjian Guo, Jacqueline M. Hirth, Abbey B. Berenson
Organization: University of Texas Medical Branch, Galveston, TX
机构：特克萨斯大学医学院
http://www.abstractsonline.com/plan/ViewAbstract.aspx?mID=3682&sKey=7f019f73-accb-484e-becc-5ecc405f8ec5&cKey=e2313b32-d6ac-4443-ab2d-49c368ea3b89&mKey=19573a54-ae8f-4e00-9c23-bd6d62268424
For the new study, Guo and his colleagues analyzed information from nearly 600 women ages 20 to 26, including 80 women who had received the original Gardasil HPV vaccine, which protects against four HPV types — 6, 11, 16 and 18.
这项新的研究中，郭方建及其同事分析了20-26岁年龄段近600位女性，其中包括80位接种过默克公司的4价HPV疫苗Gardasil，它们对HPV6、11、16与18毒株提供保护。
There are many types of HPV, and some can lead to cervical cancer if the body does not clear the infection after many years. HPV types 16 and 18 cause the majority of cervical cancers.
人乳头状瘤病毒（HPV）病毒有许多种，其中某些毒株能够导致宫颈癌，如果身体多年后仍然不能清除它们的感染。HPV16与HPV18造成大部分宫颈癌。
Women in the study who received the Gardasil vaccine were, indeed, less likely to be infected with the four strains of the virus included the vaccine: About 11 percent of vaccinated women were infected with HPV 6, 11, 16 or 18, compared with nearly 20 percent of unvaccinated women.
该项研究发现，接种了默克公司4价HPV疫苗Gardasil的女性，确实更少可能感染疫苗中含的4种毒株：接种4价HPV疫苗Gardasil的女性感染HPV6、11、16或18毒株感染率大约11%，未接种女性感染率近20%。
【评论：接种4价HPV疫苗以后，不是不再受到疫苗中含的4种毒株感染，而是受感染率减少大约9%！】
However, the women who received the vaccine were more likely to be infected with other high-risk HPV strains not included in the vaccine. About 61 percent of the women who received the vaccine were infected with another type of high-risk HPV, compared with 40 percent of women who did not receive the vaccine. (HPV strains are considered "high risk" if they can cause cellular changes that can eventually lead to cancer.)
然而，接种了这种4价HPV疫苗的女性更为容易受到疫苗中未含的其他高危HPV毒株的感染：接种了4价HPV疫苗女性受其他高危HPV毒株感染率大约为61%，而未接种这种HPV疫苗女性受其他高危HPV毒株感染率大约为40%。（造成最终可能导致癌症细胞变化的HPV毒株被考虑为“高风险”）
【评论：也就是说，接种4价HPV疫苗以后，受其他高危HPV毒株感染率风险反而增高21%！显然“得不偿失”！】
After the researchers took into account factors that could affect a person's risk of HPV infection (including his or her number of sexual partners), the women who received the original HPV vaccine still had about a 40 percent greater risk of being infected with a high-risk HPV strain not included in the vaccine. [10 Do's and Don'ts to Reduce Your Risk of Cancer]
研究者们对可能影响接种者HPV感染风险的因素后（包括他或她有多少位性交伙伴），接种4价HPV疫苗以后，受疫苗中未含HPV毒株以外其它高危HPV毒株感染率风险依然增高40%。[参看：减少你癌症风险“10种应当做的事”与“10种不应当做的事”]
【评论：也就是说，扣除性交伙伴数量多寡因素后，接种HPV疫苗以后，受其他高危HPV毒株感染率风险依然增高40%！显然更为“得不偿失”！】
It's unclear why the vaccinated women were more likely to be infected with other high-risk strains, the researchers said.
HPV疫苗接种女性为什么更容易受疫苗中未含HPV毒株以外其它高危HPV毒株感染的原因目前不清楚，研究者们说。
【评论：美国癌症研究协会2015年年会期间已经披露“HPV疫苗接种女性更容易受疫苗中未含HPV毒株以外其它高危HPV毒株感染的原因目前不清楚”情况下，葛兰素史克公司及其“帮办专家”群体与国家食品药品监管总局2016年7月宣布在中国9-25岁女童、少女中大规模接种2价HPV疫苗，只能解释为“犯罪故意”而非其他！】
The new findings suggest that women previously vaccinated against HPV may benefit from a new HPV vaccine, called Gardasil 9, which protects against the original four strains plus five more strains (31, 33, 45, 52 and 58) of HPV that cause about 20 percent of cervical cancers, the researchers said. Gardasil 9 was approved in December 2014 for women ages 9 to 26.
该项新研究的发现提议，以前接种过4价HPV疫苗的女性可能通过进一步接种新的9价HPV Gardasil 9疫苗，在预防HPV6、11、16或18毒株感染外还可以预防另外5种HPV毒株（HPV31、33、45、52与58），这些HPV毒株合起来造成宫颈癌的大约20%，研究者们说。2014年12月已经批准HPV疫苗Gardasil 9对9-26岁女童、少女、年轻女性进行接种。
And if a woman is already infected with HPV, the HPV vaccine cannot eliminate this infection, Guo noted. Younger women and girls who have not acquired an HPV infection would benefit most from the new vaccine, Guo said.
而且，如果一位女性已经感染HPV病毒，HPV疫苗无法消除这种感染，郭方建指出。尚未受到HPV病毒感染的年轻女性、少女与女童可以从这种最新的9价疫苗最大受益。
【评论：依照上述发现，尚未受到HPV病毒感染年轻女性、少女与女童从这种最新的9价疫苗获得的理论上最大限度益处仅仅是预防宫颈癌的20%！】
Because the new study looked at women at one point in time, the researchers could not determine women's risk of going on to develop cervical cancer. However previous studies have found that the HPV vaccine lowers the rate of precancerous lesions in women who are vaccinated.
由于该项新的研究仅仅对女性做一个一个时间点观察，研究者们不能确定这些女性进一步发展宫颈癌的风险。然而，以前的研究发现，HPV疫苗在接种女性中可以降低降低癌前病变率。
Studies that follow women over time would be needed in order to determine women's risk of developing cervical cancer if they were vaccinated but were to still become infected with a high-risk strain of HPV, Guo said.
需要对女性进行长期跟踪研究才能确定接种HPV疫苗后依然受到高危HPV病毒株感染的女性发展宫颈癌的风险，郭方建说。
The new study "highlights the need to continue to pursue additional strategies to control HPV infection," said Dr. Kunle Odunsi, deputy director and chairman of the department of gynecologic oncology at Roswell Park Cancer Institute in Buffalo, New York, who was not involved in the study.
该项新的研究“凸显了继续追求更多策略来控制HPV感染的需要”，Kunle Odunsi博士说，他是纽约州布法罗Roswell Park癌症研究所妇科肿瘤学科副主任与主席，没有参与该项研究。
"We need to remember that there are more than 80 HPV types, and some of them can still be associated with risk of cervical malignant disease," Odunsi said.
Kunle Odunsi博士强调，“我们必须记住HPV病毒有超过80种毒株，它们当中还有某些可能与宫颈恶性疾病风险相关”。
Future vaccines could include even more strains of the virus, Odunsi said.
未来的疫苗可以包括更多种HPV病毒株，Kunle Odunsi博士说。
Based on the new findings, Odunsi said that, in his opinion, women who received the quadrivalent vaccine should probably get the nine-valent vaccine.
基于这项新的研究的发现，Kunle Odunsi博士说，以他的看法，接种了4价HPV疫苗的女性可能还应接种新的9价HPV疫苗。
Dr. Shashikant Lele, clinical chief of gynecologic oncology, also of Roswell Park, said he would like to see the new findings replicated, because it's not clear why women who were vaccinated with the quadrivalent vaccine would be more prone to other HPV infections than women who had not received the vaccine. "That doesn't make sense to me," Lele said.
Shashikant Lele博士，Roswell Park癌症研究所妇科肿瘤临床负责人，说，他希望看到该项新研究的发现得到重复，因为HPV疫苗接种女性为什么更容易受疫苗中未含HPV毒株以外其它高危HPV毒株感染的原因目前不清楚。“这对我来说讲不通”，Lele博士说。
【评论：竭力挺“宫颈癌疫苗”专家已经思维定式，根本想象不到“HPV疫苗接种女性更容易受疫苗中未含HPV毒株以外其它高危HPV毒株感染”最有可能的原因是“宫颈癌疫苗”接种本身削弱了而不是增强了女性抵抗其他HPV病毒感染的免疫能力！】
In addition, it's not clear whether women who received the quadrivalent vaccine would benefit from the nine-valent vaccine, so studies need to be conducted to test this hypothesis, Lele said.
此外，进一步接种9价HPV疫苗是否让已接种4价HPV疫苗女性受益也不清楚，所以需做进一步的研究测试这样的假说，Lele博士说。
参考资料：
真相：少女时接种过宫颈癌疫苗奥林匹克划船银牌选手33岁时却死于宫颈癌
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博文：http://blog.sina.com.cn/s/blog_4bb17e9d0102wrw1.html
美国健康影响新闻：李善恒博士致习主席与李总理推荐中国推迟HPV疫苗接种的公开信
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华人病理学家李善恒致习近平主席、李克强总理的公开信：建议推迟实施对中国儿童年轻女性接种HPV疫苗
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中国疾控中心发布<宫颈癌疫苗:国内为何独缺席>揭示22问题
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